City will be confident of achieving their aim, having not lost Champions League group game since September 2018 – winning 13 and drawing four. And with Leipzig struggling in the Bundesliga, with three defeats in four games, only one result seems likely at the Etihad.
There’s more bad news for the visitors as Kevin de Bruyne is in contention for a starting berth after making the bench during the 1-0 over Leicester on Saturday, However, he did not feature.
Phil Foden was also an unused substitute which means the covid-positive Zak Steffan and Benjamin Mendy, who has been remanded in custody after being charged with rape and sexual assault, are the only two players not available to Guardiola.
John Stones has had little opportunity in the heart of the City defence but could rotate with Aymeric Laporte with Raheem Stirling and Riyad Mahrez also a possible starters in an attacking reshuffle.
Man City probable starting XI (4-1-2-3): Ederson; Walker, Dias, Stones, Cancelo; Rodri, Gundogan, Silva; Mahrez, De Bruyne, Sterling
Tuesday: 8pm GMT, BT Sport 3
Venue: Etihad Stadium – Manchester
Referee: Serdar Gözübüyük